EWTN Catholic Q&A
Seed of the Serpent
Question from adriana on 07-03-2018:

Who is the “Seed of the Serpent” spoken of in Genesis 3? We are all suppose to pray and forgive all, but if the serpent has descendants (people walking amongst us)do we pray & help them too? Are the descendants of the serpent amongst us today?

Answer by David Gregson on 08-15-2018:

Some have supposed the seed of the serpent are wicked spirits, e.g., fallen angels, who follow Satan as their leader. I think the stronger case can be made for their being what St Augustine called the City of Man, all those human beings enslaved by Satan, which Augustine distinguished from the City of God, those willingly subject to their Creator. That the seed of the serpent are sinful human beings seems supported by John 8:44-47. Addressing unbelievers, Jesus said, "You are of your father the devil, and your will is to do your father's desires. He was a murderer from the beginning, and has nothing to do with the truth, because there is no truth in him. When he lies, he speaks according to his own nature, for he is a liar and the father of lies."

Of course, we should pray for fallen human beings, and do what we can to bring them to the truth. It would be pointless to pray for fallen spirits.